| EC |
5.3.4.1 |
| Accepted name: |
protein disulfide-isomerase |
| Reaction: |
Catalyses the rearrangement of -S-S- bonds in proteins |
| Other name(s): |
S-S rearrangase |
| Systematic name: |
protein disulfide-isomerase |
| Comments: |
Needs reducing agents or partly reduced enzyme; the reaction depends on sulfhydryl-disulfide interchange. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37318-49-3 |
| References: |
| 1. |
De Lorenzo, F., Goldberger, R.F., Steers, E., Givol, D. and Anfinsen, C.B. Purification and properties of an enzyme from beef liver which catalyzes sulfhydryl-disulfide interchange in proteins. J. Biol. Chem. 241 (1966) 1562–1567. [PMID: 5946614] |
| 2. |
Fuchs, S., De Lorenzo, F. and Anfinsen, C.B. Studies on the mechanism of the enzymic catalysis of disulfide interchange in proteins. J. Biol. Chem. 242 (1967) 398–402. [PMID: 6022836] |
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| [EC 5.3.4.1 created 1972] |
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