ExplorEnz: EC 5.3.3.7

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5.3.3.7

Accepted name:

aconitate Δ-isomerase

Reaction:

trans-aconitate = cis-aconitate

Glossary:

cis-aconitate = (Z)-prop-1-ene-1,2,3-tricarboxylate
trans-aconitate = (E)-prop-1-ene-1,2,3-tricarboxylate

Other name(s):

aconitate isomerase

Systematic name:

aconitate Δ²-Δ³-isomerase

Comments:

cis-Aconitate is used to designate the isomer (Z)-prop-1-ene-1,2,3-tricarboxylate. This isomerization could take place either in a direct cis-trans interconversion or by an allylic rearrangement; the enzyme has been shown to catalyse the latter change.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 37318-48-2

References:

1.	Klinman, J.P. and Rose, I.A. Purification and kinetic properties of aconitate isomerase from Pseudomonas putida. Biochemistry 10 (1971) 2253–2259. [PMID: 5114987]
2.	Klinman, J.P. and Rose, I.A. Mechanism of the aconitate isomerase reaction. Biochemistry 10 (1971) 2259–2266. [PMID: 5114988]

[EC 5.3.3.7 created 1972]