ExplorEnz: EC 5.3.3.22

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5.3.3.22

Accepted name:

lutein isomerase

Reaction:

lutein = meso-zeaxanthin

For diagram of lutein biosynthesis, click here

Glossary:

lutein = (3R,3′R)-dihydroxy-α-carotene
meso-zeaxanthin = (3R,3′S)-β,β-carotene-3,3′-diol

Other name(s):

RPE65 (gene name); meso-zeaxanthin isomerase

Systematic name:

lutein Δ⁴-Δ⁵-isomerase

Comments:

The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB

References:

1.	Shyam, R., Gorusupudi, A., Nelson, K., Horvath, M.P. and Bernstein, P.S. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc. Natl. Acad. Sci. USA 114 (2017) 10882–10887. [DOI] [PMID: 28874556]

[EC 5.3.3.22 created 2018]