The Enzyme Database

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EC 5.3.3.22     
Accepted name: lutein isomerase
Reaction: lutein = meso-zeaxanthin
For diagram of lutein biosynthesis, click here
Glossary: lutein = (3R,3′R)-dihydroxy-α-carotene
meso-zeaxanthin = (3R,3′S)-β,β-carotene-3,3′-diol
Other name(s): RPE65 (gene name); meso-zeaxanthin isomerase
Systematic name: lutein Δ45-isomerase
Comments: The enzyme is found in the retinal pigment epithelium (RPE) of vertebrates. It also has the activity of EC 3.1.1.64, retinoid isomerohydrolase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Shyam, R., Gorusupudi, A., Nelson, K., Horvath, M.P. and Bernstein, P.S. RPE65 has an additional function as the lutein to meso-zeaxanthin isomerase in the vertebrate eye. Proc. Natl Acad. Sci. USA 114 (2017) 10882–10887. [DOI] [PMID: 28874556]
[EC 5.3.3.22 created 2018]
 
 


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