ExplorEnz: EC 5.3.3.10

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5.3.3.10

Accepted name:

5-carboxymethyl-2-hydroxymuconate Δ-isomerase

Reaction:

5-carboxymethyl-2-hydroxymuconate = (3E,5R)-5-carboxy-2-oxohept-3-enedioate

Glossary:

5-carboxymethyl-2-hydroxymuconate = (2E,4Z)-5-hydroxypenta-2,4-diene-1,2,5-tricarboxylate

Other name(s):

CHM isomerase; 5-carboxymethyl-2-hydroxymuconic acid isomerase

Systematic name:

5-carboxymethyl-2-hydroxymuconate Δ²,Δ⁴-2-oxo,Δ³-isomerase

Comments:

Part of the homoprotocatechuate degradation pathway in Escherichia coli C.

Links to other databases:

BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 79079-05-3

References:

1.	Garrido-Pertierra, A. and Cooper, R.A. Identification and purification of distinct isomerase and decarboxylase enzymes involved in the 4-hydroxyphenylacetate pathway of Escherichia coli. Eur. J. Biochem. 117 (1981) 581–584. [DOI] [PMID: 7026235]
2.	Johnson, W.H., Jr., Hajipour, G. and Whitman, C.P. Stereochemical studies of 5-(carboxymethyl)-2-hydroxymuconate isomerase and 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dioate decarboxylase from Escherichia coli C: mechanistic and evolutionary implications. J. Am. Chem. Soc. 117 (1995) 8719–8726.

[EC 5.3.3.10 created 1984]