EC |
5.3.1.21 |
Accepted name: |
corticosteroid side-chain-isomerase |
Reaction: |
11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al |
Systematic name: |
11-deoxycorticosterone aldose-ketose-isomerase |
Comments: |
An epimerization at C-20 and C-21 is probably catalysed by the same enzyme. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 75139-73-0 |
References: |
1. |
Martin, K.O., Oh, S.-W., Lee, H.J. and Monder, C. Studies on 21-3H-labeled corticosteroids: evidence for isomerization of the ketol side chain of 11-deoxycorticosterone by a hamster liver enzyme. Biochemistry 16 (1977) 3803–3809. [PMID: 901753] |
2. |
Monder, C., Martin, K.O. and Bogumil, J. Presence of epimerase activity in hamster liver corticosteroid side chain isomerase. J. Biol. Chem. 255 (1980) 7192–7198. [PMID: 7391077] |
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[EC 5.3.1.21 created 1983] |
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