ExplorEnz: EC 5.1.3.9

Your query returned 1 entry. Printable version

5.1.3.9

Accepted name:

N-acylglucosamine-6-phosphate 2-epimerase

Reaction:

N-acyl-D-glucosamine 6-phosphate = N-acyl-D-mannosamine 6-phosphate

Other name(s):

acylglucosamine-6-phosphate 2-epimerase; acylglucosamine phosphate 2-epimerase

Systematic name:

N-acyl-D-glucosamine-6-phosphate 2-epimerase

Comments:

The enzyme found in bacteria accepts N-acetyl and N-glycoloyl derivatives [1].

Links to other databases:

BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 37318-35-7

References:

1.	Ghosh, S. and Roseman, S. The sialic acids. IV. N-Acyl-D-glucosamine 6-phosphate 2-epimerase. J. Biol. Chem. 240 (1965) 1525–1530. [DOI] [PMID: 14285487]
2.	Manjunath, L., Guntupalli, S.R., Currie, M.J., North, R.A., Dobson, R.CJ., Nayak, V. and Subramanian, R. Crystal structures and kinetic analyses of N-acetylmannosamine-6-phosphate 2-epimerases from Fusobacterium nucleatum and Vibrio cholerae. Acta Crystallogr. F Struct. Biol. Commun. 74 (2018) 431–440. [DOI] [PMID: 29969107]
3.	Currie, M.J., Manjunath, L., Horne, C.R., Rendle, P.M., Subramanian, R., Friemann, R., Fairbanks, A.J., Muscroft-Taylor, A.C., North, R.A. and Dobson, R.CJ. N-acetylmannosamine-6-phosphate 2-epimerase uses a novel substrate-assisted mechanism to catalyze amino sugar epimerization. J. Biol. Chem. 297:101113 (2021). [DOI] [PMID: 34437902]

[EC 5.1.3.9 created 1972]