ExplorEnz: EC 5.1.1.27

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5.1.1.27

Accepted name:

cysteinolate racemase

Reaction:

D-cysteinolate = L-cysteinolate

Glossary:

cysteinolate = 2-amino-3-hydroxypropane-1-sulfonate
D-cysteinolate = (2S)-2-amino-3-hydroxypropane-1-sulfonate
L-cysteinolate = (2R)-2-amino-3-hydroxypropane-1-sulfonate

Other name(s):

claA (gene name); cuyC (gene name); cysteinolic acid racemase

Systematic name:

cysteinolate racemase

Comments:

A pyridoxal 5′-phosphate dependent protein. This enzyme, characterized from the bacteria Ruegeria pomeroyi and Bilophila sp. 4_1_30, participates in a D-cysteinolate degradation pathway.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Burchill, L., Stewart, A.WE., Pallasdies, L., Lee, M., Coe, L.SY., Zudich, L., Jebeli, L., Sharma, M., Hofferek, V., McConville, M.J., Davies, G.J., Scott, N.E., Durham, B.P. and Williams, S.J. Bridging a gap in marine sulfur cycling: discovery of a D-cysteinolic acid degradation pathway. J. Am. Chem. Soc. 147 (2025) 47934–47941. [DOI] [PMID: 41404639]
2.	Liu, X., Hu, Y., An, J., Zhang, C., Tan, J., Wei, Y. and Zhang, Y. A pathway for D-cysteinolate degradation in sulfate- and sulfite-reducing bacteria. J. Biol. Chem. 302:111055 (2026). [DOI] [PMID: 41391761]

[EC 5.1.1.27 created 2026]