ExplorEnz: EC 5.1.1.15

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5.1.1.15

Accepted name:

2-aminohexano-6-lactam racemase

Reaction:

(S)-2-aminohexano-6-lactam = (R)-2-aminohexano-6-lactam

Glossary:

(S)-2-aminohexano-6-lactam = L-lysine 1,6-lactam

Other name(s):

α-amino-ε-caprolactam racemase

Systematic name:

2-aminohexano-6-lactam racemase

Comments:

Contains pyridoxal 5′-phosphate. Also racemises 2-aminopentano-5-lactam (α-amino-δ-valerolactam) and 2-amino-4-thiahexano-6-lactam (where S replaces CH₂ of C-4). It does not catalyse the racemisation of α-amino acids but has some transaminase activity with them.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 52652-64-9

References:

1.	Ahmed, S.A., Esaki, N., Tanaka, H., Soda, K. L-α-Amino-β-thio-ε-caprolactam, a new sulfur-containing substrate for α-amino-ε-caprolactam racemase. FEBS Lett. 174 (1984) 76–79.
2.	Ahmed, S.A., Esaki, N., Tanaka, H., Soda, K. Mechanism of α-amino-ε-caprolactam racemase reaction. Biochemistry 25 (1986) 385–388. [PMID: 3955003]
3.	Okazaki, S., Suzuki, A., Mizushima, T., Kawano, T., Komeda, H., Asano, Y. and Yamane, T. The novel structure of a pyridoxal 5′-phosphate-dependent fold-type I racemase, α-amino-ε-caprolactam racemase from Achromobacter obae. Biochemistry 48 (2009) 941–950. [DOI] [PMID: 19146406]

[EC 5.1.1.15 created 1999]