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| EC | 5.1.1.14 | ||||||
| Accepted name: | nocardicin A epimerase | ||||||
| Reaction: | (1) isonocardicin C = nocardicin C (2) isonocardicin A = nocardicin A |
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| For diagram of nocardicin biosynthesis, click here and for diagram of nocardicin A biosynthesis, click here | |||||||
| Glossary: | nocardicin A = (2R)-2-amino-4-{4-[(1E)-{[(3S)-1-[(R)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}butanoic acid isonocardicin A =(2S)-2-amino-4-{4-[(1E)-{[(3S)-1-[(R)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl}(hydroxyimino)methyl]phenoxy}butanoic acid nocardicin C = (2R)-2-amino-4-{4-[(R)-amino({[(3S)-1-[(R)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl})methyl]phenoxy}butanoic acid isonocardicin C = (2S)-2-amino-4-{4-[(R)-amino({[(3S)-1-[(R)-carboxy(4-hydroxyphenyl)methyl]-2-oxoazetidin-3-yl]carbamoyl})methyl]phenoxy}butanoic acid |
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| Other name(s): | isonocardicin A epimerase; nocJ (gene name) | ||||||
| Systematic name: | nocardicin-C epimerase | ||||||
| Comments: | Requires pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium Nocardia uniformis, is involved in the biosynthesis of the monolactam antibiotic nocardicin A. It catalyses the epimerization of the amino group at position 9′ from (S)- configuration to (R)-. The enzyme can act on both isonocardicin A and isonocardicin C, but the in vivo substrate appears to be the latter [3]. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 118246-75-6 | ||||||
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