| EC |
4.98.1.1 |
| Accepted name: |
protoporphyrin ferrochelatase |
| Reaction: |
protoheme + 2 H+ = protoporphyrin + Fe2+ |
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For diagram of heme and chlorophyll biosynthesis, click here |
| Other name(s): |
ferro-protoporphyrin chelatase; iron chelatase (ambiguous); heme synthetase (ambiguous); heme synthase (ambiguous); protoheme ferro-lyase; ferrochelatase (ambiguous) |
| Systematic name: |
protoheme ferro-lyase (protoporphyrin-forming) |
| Comments: |
The enzyme catalyses the terminal step in the heme biosynthesis pathways of eukaryotes and Gram-negative bacteria. The reaction is catalysed only in the reverse direction. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 9012-93-5 |
| References: |
| 1. |
Porra, R.J. and Jones, O.T. Studies on ferrochelatase. 1. Assay and properties of ferrochelatase from a pig-liver mitochondrial extract. Biochem. J. 87 (1963) 181–185. [PMID: 13972328] |
| 2. |
Porra, R.J. and Jones, O.T. Studies on ferrochelatase. 2. An investigation of the role
of ferrochelatase in the biosynthesis of various haem prosthetic groups. Biochem. J. 87 (1963) 186–192. [PMID: 13972329] |
| 3. |
Bloomer, J.R., Hill, H.D., Morton, K.O., Anderson-Burnham, L.A. and Straka, J.G. The enzyme defect in bovine protoporphyria. Studies with purified ferrochelatase. J. Biol. Chem. 262 (1987) 667–671. [PMID: 3805002] |
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| [EC 4.98.1.1 created 1965 as EC 4.99.1.1, modified 2016, transferred 2021 to EC 4.98.1.1] |
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