| EC |
4.6.1.2 |
| Accepted name: |
guanylate cyclase |
| Reaction: |
GTP = 3′,5′-cyclic GMP + diphosphate |
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For diagram of GTP biosynthesis, click here |
| Other name(s): |
guanylyl cyclase; guanyl cyclase; GTP diphosphate-lyase (cyclizing) |
| Systematic name: |
GTP diphosphate-lyase (cyclizing; 3′,5′-cyclic-GMP-forming) |
| Comments: |
Also acts on ITP and dGTP. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9054-75-5 |
| References: |
| 1. |
Garbers, D.L., Suddath, J.L. and Hardman, J.G. Enzymatic formation of inosine 3′,5′-monophosphate and of 2′-deoxyguanosine 3′,5′-monophosphate. Inosinate and deoxyguanylate cyclase activity. Biochim. Biophys. Acta 377 (1975) 174–185. [DOI] [PMID: 235291] |
| 2. |
Hardman, J.G. and Sutherland, E.W. Guanyl cyclase, an enzyme catalyzing the formation of guanosine 3′,5′-monophosphate from guanosine triphosphate. J. Biol. Chem. 244 (1969) 6363–6370. [PMID: 4982201] |
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| [EC 4.6.1.2 created 1972] |
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