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Your query returned 1 entry. Printable version
EC | 4.4.1.36 | ||||||
Accepted name: | hercynylcysteine S-oxide lyase | ||||||
Reaction: | S-(hercyn-2-yl)-L-cysteine S-oxide + reduced acceptor = ergothioneine + pyruvate + NH3 + acceptor (overall reaction) (1a) S-(hercyn-2-yl)-L-cysteine S-oxide + H2O = 2-(hydroxysulfanyl)hercynine + pyruvate + NH3 (1b) 2-(hydroxysulfanyl)hercynine + reduced acceptor = ergothioneine + acceptor + H2O (spontaneous) |
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Glossary: | 2-(hydroxysulfanyl)hercynine = Nα,Nα,Nα-trimethyl-2-(hydroxysulfanyl)-L-histidine = 2-sulfenohercynine ergothioneine = Nα,Nα,Nα-trimethyl-2-sulfanylidene-2,3-dihydro-L-histidine |
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Other name(s): | egtE (gene name) | ||||||
Systematic name: | S-(hercyn-2-yl)-L-cysteine ergothioneine-hydroxysulfanolate-lyase | ||||||
Comments: | Contains pyridoxal 5′-phosphate. The enzyme, characterized from the bacterium Mycobacterium smegmatis, cayalyses the last step in the pathway of ergothioneine biosynthesis. The enzyme forms a 2-(hydroxysulfanyl)hercynine intermediate, which is reduced to ergothioneine non-enzymically by a thiol. In vitro, DTT can serve this function. | ||||||
Links to other databases: | BRENDA, EXPASY, Gene, KEGG, MetaCyc | ||||||
References: |
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