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Your query returned 1 entry. Printable version
EC | 4.4.1.23 | ||||||
Accepted name: | 2-hydroxypropyl-CoM lyase | ||||||
Reaction: | (1) (R)-2-hydroxypropyl-CoM = (R)-1,2-epoxypropane + HS-CoM (2) (S)-2-hydroxypropyl-CoM = (S)-1,2-epoxypropane + HS-CoM |
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For diagram of epoxide carboxylation, click here | |||||||
Glossary: | coenzyme M (CoM) = 2-sulfanylethane-1-sulfonate = 2-mercaptoethanesulfonate (deprecated) | ||||||
Other name(s): | epoxyalkane:coenzyme M transferase; epoxyalkane:CoM transferase; epoxyalkane:2-mercaptoethanesulfonate transferase; coenzyme M-epoxyalkane ligase; epoxyalkyl:CoM transferase; epoxypropane:coenzyme M transferase; epoxypropyl:CoM transferase; EaCoMT; 2-hydroxypropyl-CoM:2-mercaptoethanesulfonate lyase (epoxyalkane-ring-forming); (R)-2-hydroxypropyl-CoM 2-mercaptoethanesulfonate lyase (cyclizing; (R)-1,2-epoxypropane-forming) | ||||||
Systematic name: | (R)[or (S)]-2-hydroxypropyl-CoM:2-sulfanylethane-1-sulfonate lyase (epoxyalkane-ring-forming) | ||||||
Comments: | Requires zinc. Acts on both enantiomers of chiral epoxyalkanes to form the corresponding (R)- and (S)-2-hydroxyalkyl-CoM adducts. The enzyme will function with some other thiols (e.g., 2-sulfanylethanol) as the nucleophile. Uses short-chain epoxyalkanes from C2 (epoxyethane) to C6 (1,2-epoxyhexane). This enzyme forms component I of a four-component enzyme system (comprising EC 4.4.1.23 (2-hydroxypropyl-CoM lyase; component I), EC 1.8.1.5 [2-oxopropyl-CoM reductase (carboxylating); component II], EC 1.1.1.268 [2-(R)-hydroxypropyl-CoM dehydrogenase; component III] and EC 1.1.1.269 [2-(S)-hydroxypropyl-CoM dehydrogenase; component IV]) that is involved in epoxyalkane carboxylation in Xanthobacter sp. strain Py2. | ||||||
Links to other databases: | BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, CAS registry number: 244301-07-3 | ||||||
References: |
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