The Enzyme Database

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Accepted name: nitrosuccinate lyase
Reaction: 2-nitrobutanedioate = fumarate + nitrite
Glossary: 2-nitrobutanedioate = nitrosuccinate
Other name(s): creD (gene name)
Systematic name: 2-nitrobutanedioate lyase (fumarate-forming)
Comments: The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Sugai, Y., Katsuyama, Y. and Ohnishi, Y. A nitrous acid biosynthetic pathway for diazo group formation in bacteria. Nat. Chem. Biol. 12 (2016) 73–75. [DOI] [PMID: 26689788]
2.  Hagihara, R., Katsuyama, Y., Sugai, Y., Onaka, H. and Ohnishi, Y. Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis. J. Antibiot. (Tokyo) 71 (2018) 911–919. [DOI] [PMID: 30120394]
[EC created 2021]

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