| EC |
4.3.99.5 |
| Accepted name: |
nitrosuccinate lyase |
| Reaction: |
2-nitrobutanedioate = fumarate + nitrite |
| Glossary: |
2-nitrobutanedioate = nitrosuccinate |
| Other name(s): |
creD (gene name) |
| Systematic name: |
2-nitrobutanedioate lyase (fumarate-forming) |
| Comments: |
The enzyme, found in some Actinobacteria, is involved in a pathway that forms nitrite, which is subsequently used to generate a diazo group in some secondary metabolites. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Sugai, Y., Katsuyama, Y. and Ohnishi, Y. A nitrous acid biosynthetic pathway for diazo group formation in bacteria. Nat. Chem. Biol. 12 (2016) 73–75. [DOI] [PMID: 26689788] |
| 2. |
Hagihara, R., Katsuyama, Y., Sugai, Y., Onaka, H. and Ohnishi, Y. Novel desferrioxamine derivatives synthesized using the secondary metabolism-specific nitrous acid biosynthetic pathway in Streptomyces davawensis. J. Antibiot. (Tokyo) 71 (2018) 911–919. [DOI] [PMID: 30120394] |
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| [EC 4.3.99.5 created 2021] |
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