| EC |
4.3.2.4 |
| Accepted name: |
purine imidazole-ring cyclase |
| Reaction: |
DNA 4,6-diamino-5-formamidopyrimidine = DNA adenine + H2O |
| Other name(s): |
DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing); DNA-4,6-diamino-5-formamidopyrimidine 8-C,9-N-lyase (cyclizing; DNA-adenine-forming) |
| Systematic name: |
DNA-4,6-diamino-5-formamidopyrimidine C8-N9-lyase (cyclizing; DNA-adenine-forming) |
| Comments: |
Also acts on 2,6-diamino-5-formamido-3,4-dihydro-4-oxopyrimidine residues. Brings about the reclosure of the imidazole rings of purine residues damaged by γ-rays. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number: 95990-28-6 |
| References: |
| 1. |
Chetsanga, C.J. and Grigorian, C. In situ enzymatic reclosure of opened imidazole rings of purines in DNA damaged by γ-irradiation. Proc. Natl. Acad. Sci. USA 82 (1985) 633–637. [DOI] [PMID: 3856219] |
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| [EC 4.3.2.4 created 1989] |
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