| EC |
4.2.99.21 |
| Accepted name: |
isochorismate lyase |
| Reaction: |
isochorismate = salicylate + pyruvate |
| Other name(s): |
salicylate biosynthesis protein pchB; pyochelin biosynthetic protein PchB; isochorismate pyruvate lyase |
| Systematic name: |
isochorismate pyruvate-lyase (salicylate-forming) |
| Comments: |
This enzyme is part of the pathway of salicylate formation from chorismate, and forms an integral part of pathways that produce salicylate-derived siderophores, such as pyochelin and yersiniabactin. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Serino, L., Reimmann, C., Baur, H., Beyeler, M., Visca, P. and Haas, D. Structural genes for salicylate biosynthesis from chorismate in Pseudomonas aeruginosa. Mol. Gen. Genet. 249 (1995) 217–228. [PMID: 7500944] |
| 2. |
Kerbarh, O., Ciulli, A., Howard, N.I. and Abell, C. Salicylate biosynthesis: overexpression, purification, and characterization of Irp9, a bifunctional salicylate synthase from Yersinia enterocolitica. J. Bacteriol. 187 (2005) 5061–5066. [DOI] [PMID: 16030197] |
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| [EC 4.2.99.21 created 2010] |
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