EC |
4.2.3.96 |
Accepted name: |
avermitilol synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate + H2O = avermitilol + diphosphate |
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For diagram of bicyclogermacrene and avermitilol biosynthesis, click here |
Systematic name: |
avermitilol hydrolase (cyclizing, avermitilol-forming) |
Comments: |
Requires Mg2+. The recombinent enzyme gives avermitilol (85%) plus traces of germacrene A, germacrene B and viridiflorol. The (1S)-hydrogen of farnesyl diphosphate is retained. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Chou, W.K., Fanizza, I., Uchiyama, T., Komatsu, M., Ikeda, H. and Cane, D.E. Genome mining in Streptomyces avermitilis: cloning and characterization of SAV_76, the synthase for a new sesquiterpene, avermitilol. J. Am. Chem. Soc. 132 (2010) 8850–8851. [DOI] [PMID: 20536237] |
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[EC 4.2.3.96 created 2012] |
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