The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: α-guaiene synthase
Reaction: (2E,6E)-farnesyl diphosphate = α-guaiene + diphosphate
For diagram of guaiene, α-gurjunene, patchoulol and viridiflorene biosynthesis, click here
Other name(s): PatTps177 (gene name)
Systematic name: (2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-guaiene-forming)
Comments: Requires Mg2+. The enzyme from Pogostemon cablin gives 13% α-guaiene as well as 37% (-)-patchoulol (see EC, 13% δ-guaiene (see EC, and traces of at least ten other sesquiterpenoids [1]. In Aquilaria crassna three clones of the enzyme gave about 80% δ-guaiene and 20% α-guaiene, with traces of α-humulene. A fourth clone gave 54% δ-guaiene and 45% α-guaiene [2].
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Deguerry, F., Pastore, L., Wu, S., Clark, A., Chappell, J. and Schalk, M. The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases. Arch. Biochem. Biophys. 454 (2006) 123–136. [DOI] [PMID: 16970904]
2.  Kumeta, Y. and Ito, M. Characterization of δ-guaiene synthases from cultured cells of Aquilaria, responsible for the formation of the sesquiterpenes in agarwood. Plant Physiol. 154 (2010) 1998–2007. [DOI] [PMID: 20959422]
[EC created 2011]

Data © 2001–2022 IUBMB
Web site © 2005–2022 Andrew McDonald