EC |
4.2.3.87 |
Accepted name: |
α-guaiene synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate = α-guaiene + diphosphate |
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For diagram of guaiene, α-gurjunene, patchoulol and viridiflorene biosynthesis, click here |
Other name(s): |
PatTps177 (gene name) |
Systematic name: |
(2Z,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, α-guaiene-forming) |
Comments: |
Requires Mg2+. The enzyme from Pogostemon cablin gives 13% α-guaiene as well as 37% (-)-patchoulol (see EC 4.2.3.70), 13% δ-guaiene (see EC 4.2.3.93), and traces of at least ten other sesquiterpenoids [1]. In Aquilaria crassna three clones of the enzyme gave about 80% δ-guaiene and 20% α-guaiene, with traces of α-humulene. A fourth clone gave 54% δ-guaiene and 45% α-guaiene [2]. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Deguerry, F., Pastore, L., Wu, S., Clark, A., Chappell, J. and Schalk, M. The diverse sesquiterpene profile of patchouli, Pogostemon cablin, is correlated with a limited number of sesquiterpene synthases. Arch. Biochem. Biophys. 454 (2006) 123–136. [DOI] [PMID: 16970904] |
2. |
Kumeta, Y. and Ito, M. Characterization of δ-guaiene synthases from cultured cells of Aquilaria, responsible for the formation of the sesquiterpenes in agarwood. Plant Physiol. 154 (2010) 1998–2007. [DOI] [PMID: 20959422] |
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[EC 4.2.3.87 created 2011] |
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