| EC |
4.2.3.38 |
| Accepted name: |
α-bisabolene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = (E)-α-bisabolene + diphosphate |
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For diagram of bisabolene-derived sesquiterpenoid biosynthesis, click here |
| Other name(s): |
bisabolene synthase |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [(E)-α-bisabolene-forming] |
| Comments: |
This cytosolic sesquiterpenoid synthase requires a divalent cation cofactor (Mg2+ or, to a lesser extent, Mn2+) to neutralize the negative charge of the diphosphate leaving group. While unlikely to encounter geranyl diphosphate (GDP) in vivo as it is localized to plastids, the enzyme can use GDP as a substrate in vitro to produce (+)-(4R)-limonene [cf. EC 4.2.3.20, (R)-limonene synthase]. The enzyme is induced as part of a defense mechanism in the grand fir Abies grandis as a response to stem wounding. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Bohlmann, J., Crock, J., Jetter, R. and Croteau, R. Terpenoid-based defenses in conifers: cDNA cloning, characterization, and functional expression of wound-inducible (E)-α-bisabolene synthase from grand fir (Abies grandis). Proc. Natl. Acad. Sci. USA 95 (1998) 6756–6761. [DOI] [PMID: 9618485] |
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| [EC 4.2.3.38 created 2009] |
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