ExplorEnz: EC 4.2.3.218

4.2.3.218

Accepted name:

variediene synthase

Reaction:

geranylgeranyl diphosphate = variediene + diphosphate

Glossary:

variediene = (3aR,3bS,6E,10Z,11aR)-3,3,6,10,11a-pentamethyl-2,3,3a,3b,4,5,8,9,11,11a-decahydro-1H-cyclonona[a]pentalene

Other name(s):

EvVS

Systematic name:

geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, variediene-forming)

Comments:

A diterpenoid synthase enzyme isolated from the fungus Aspergillus stellatus.

References:

Qin, B., Matsuda, Y., Mori, T., Okada, M., Quan, Z., Mitsuhashi, T., Wakimoto, T. and Abe, I. An unusual chimeric diterpene synthase from Emericella variecolor and its functional conversion into a sesterterpene synthase by domain swapping. Angew. Chem. Int. Ed. Engl. 55 (2016) 1658–1661. [PMID: 26546087]

[EC 4.2.3.218 created 2023]