The Enzyme Database

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Accepted name: vetispiradiene synthase
Reaction: (2E,6E)-farnesyl diphosphate = vetispiradiene + diphosphate
For diagram of eremophilane and spirovetivane sesquiterpenoid biosynthesis, click here
Other name(s): vetispiradiene-forming farnesyl pyrophosphate cyclase; pemnaspirodiene synthase; HVS; vetispiradiene cyclase
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (cyclizing, vetispiradiene-forming)
Comments: The initial internal cyclization produces the monocyclic intermediate germacrene A.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 192465-18-2
1.  Back, K. and Chappell, J. Cloning and bacterial expression of a sesquiterpene cyclase from Hyoscyamus muticus and its molecular comparison to related terpene cyclases. J. Biol. Chem. 270 (1995) 7375–7381. [DOI] [PMID: 7706281]
2.  Keller, H., Czernic, P., Ponchet, M., Ducrot, P.H., Back, K., Chappell, J., Ricci, P. and Marco, Y. Sesquiterpene cyclase is not a determining factor for elicitor- and pathogen-induced capsidiol accumulation in tobacco. Planta 205 (1998) 467–476.
3.  Mathis, J.R., Back, K., Starks, C., Noel, J., Poulter, C.D. and Chappell, J. Pre-steady-state study of recombinant sesquiterpene cyclases. Biochemistry 36 (1997) 8340–8348. [DOI] [PMID: 9204881]
4.  Yoshioka, H., Yamada, N. and Doke, N. cDNA cloning of sesquiterpene cyclase and squalene synthase, and expression of the genes in potato tuber infected with Phytophthora infestans. Plant Cell Physiol. 40 (1999) 993–998. [PMID: 10588069]
5.  Martin, V.J., Yoshikuni, Y. and Keasling, J.D. The in vivo synthesis of plant sesquiterpenes by Escherichia coli. Biotechnol. Bioeng. 75 (2001) 497–503. [PMID: 11745124]
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