The Enzyme Database

Your query returned 1 entry.    printer_iconPrintable version

Accepted name: hydropyrenol synthase
Reaction: geranylgeranyl diphosphate + H2O = hydropyrenol + diphosphate
Glossary: hydropyrenol = (1R,3aR,3a1S,4S,5aR,5a1S,8aS,10aS)-1,4,5a,8a-tetramethylhexadecahydropyren-4-ol
Other name(s): HpS
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cyclizing, hydropyrenol-forming)
Comments: Isolated from the bacterium Streptomyces clavuligerus. The 1-proR hydrogen atom of geranylgeranyl diphosphate is lost in the reaction. The enzyme also produces hydropyrene, isoelisabethatriene and traces of other diterpenoids. cf. EC, hydropyrene synthase, and EC, isoelisabethatriene synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Rinkel, J., Rabe, P., Chen, X., Kollner, T.G., Chen, F. and Dickschat, J.S. Mechanisms of the diterpene cyclases β-pinacene synthase from Dictyostelium discoideum and hydropyrene synthase from Streptomyces clavuligerus. Chem. Eur. J. 23 (2017) 10501–10505. [PMID: 28696553]
[EC created 2019]

Data © 2001–2022 IUBMB
Web site © 2005–2022 Andrew McDonald