The Enzyme Database

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Accepted name: 9,13-epoxylabd-14-ene synthase
Reaction: peregrinol diphosphate = (13R)-9,13-epoxylabd-14-ene + diphosphate
For diagram of hydroxylabdenyl diphosphate derived diterpenoids, click here
Glossary: peregrinol diphosphate = (13E)-9-hydroxy-8α-labd-13-en-15-yl diphosphate
Other name(s): ELS (gene name); TPS2 (gene name) (ambiguous); peregrinol-diphosphate diphosphate-lyase (9,13-epoxylabd-14-ene-forming)
Systematic name: peregrinol-diphosphate diphosphate-lyase [(13R)-9,13-epoxylabd-14-ene-forming]
Comments: Isolated from the plants Marrubium vulgare (white horehound) and Vitex agnus-castus (chaste tree). Involved in marrubiin biosynthesis.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Zerbe, P., Chiang, A., Dullat, H., O'Neil-Johnson, M., Starks, C., Hamberger, B. and Bohlmann, J. Diterpene synthases of the biosynthetic system of medicinally active diterpenoids in Marrubium vulgare. Plant J. 79 (2014) 914–927. [DOI] [PMID: 24990389]
2.  Heskes, A.M., Sundram, T.CM., Boughton, B.A., Jensen, N.B., Hansen, N.L., Crocoll, C., Cozzi, F., Rasmussen, S., Hamberger, B., Hamberger, B., Staerk, D., Møller, B.L. and Pateraki, I. Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. Plant J. 93 (2018) 943–958. [PMID: 29315936]
[EC created 2017]

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