Accepted name: nezukol synthase
Reaction: (+)-copalyl diphosphate + H2O = nezukol + diphosphate
Glossary: (+)-copalyl diphosphate = (2E)-3-methyl-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]pent-2-en-1-yl trihydrogen diphosphate
nezukol = pimar-15-en-8-ol
Other name(s): TPS2
Systematic name: (+)-copalyl-diphosphate diphosphate-lyase (cyclizing, nezukol-forming)
Comments: Isolated from the plant Isodon rubescens.
1.  Pelot, K.A., Hagelthorn, D.M., Addison, J.B. and Zerbe, P. Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases. PLoS One 12:e0176507 (2017). [PMID: 28445526]
[EC created 2017]