ExplorEnz: EC 4.2.3.183

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4.2.3.183

Accepted name:

nezukol synthase

Reaction:

(+)-copalyl diphosphate + H₂O = nezukol + diphosphate

For diagram of pimarane diterpenoids biosynthesis, click here

Glossary:

(+)-copalyl diphosphate = (2E)-3-methyl-5-[(1S,4aS,8aS)-5,5,8a-trimethyl-2-methylidenedecahydronaphthalen-1-yl]pent-2-en-1-yl trihydrogen diphosphate
nezukol = pimar-15-en-8-ol

Other name(s):

TPS2

Systematic name:

(+)-copalyl-diphosphate diphosphate-lyase (cyclizing, nezukol-forming)

Comments:

Isolated from the plant Isodon rubescens.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Pelot, K.A., Hagelthorn, D.M., Addison, J.B. and Zerbe, P. Biosynthesis of the oxygenated diterpene nezukol in the medicinal plant Isodon rubescens is catalyzed by a pair of diterpene synthases. PLoS One 12:e0176507 (2017). [DOI] [PMID: 28445526]

[EC 4.2.3.183 created 2017]