EC |
4.2.3.171 |
Accepted name: |
(+)-corvol ether A synthase |
Reaction: |
(2E,6E)-farnesyl diphosphate + H2O = (+)-corvol ether A + diphosphate |
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For diagram of corvol ether A and corvol ether B biosynthesis, click here |
Glossary: |
(+)-corvol ether A = (1R,4S,4aR,7R,8aR)-4,7-dimethyl-1-(propan-2-yl)decahydro-1,7-epoxynaphthalene |
Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lyase [cyclizing, (+)-corvol ether A-forming] |
Comments: |
The enzyme, which forms the sesquiterpene (+)-corvol ether A, has been reported from the bacterium Kitasatospora setae. |
Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
References: |
1. |
Rabe, P., Pahirulzaman, K.A. and Dickschat, J.S. Structures and biosynthesis of corvol ethers—sesquiterpenes from the actinomycete Kitasatospora setae. Angew. Chem. Int. Ed. Engl. 54 (2015) 6041–6045. [DOI] [PMID: 25809275] |
2. |
Rabe, P., Janusko, A., Goldfuss, B. and Dickschat, J.S. Experimental and theoretical studies on corvol ether biosynthesis. ChemBioChem 17 (2016) 146–149. [DOI] [PMID: 26635093] |
3. |
Rinkel, J., Rabe, P., Garbeva, P. and Dickschat, J.S. Lessons from 1,3-hydride shifts in sesquiterpene cyclizations. Angew. Chem. Int. Ed. Engl. 55 (2016) 13593–13596. [DOI] [PMID: 27666571] |
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[EC 4.2.3.171 created 2017] |
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