The Enzyme Database

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Accepted name: cembrene C synthase
Reaction: geranylgeranyl diphosphate = cembrene C + diphosphate
For diagram of cembrene and related diterpenoids, click here
Glossary: cembrene C = (1E,5E,9E)-1,5,9-trimethyl-12-(propan-2-ylidene)cyclotetradeca-1,5,9-triene
Other name(s): DtcycA (gene name)
Systematic name: geranylgeranyl-diphosphate diphosphate-lyase (cembrene-C-forming)
Comments: Requires Mg2+. Isolated from the bacterium Streptomyces sp. SANK 60404. This bifunctional enzyme also produces (R)-nephthenol. See EC, nephthenol synthase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Meguro, A., Tomita, T., Nishiyama, M. and Kuzuyama, T. Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. ChemBioChem 14 (2013) 316–321. [DOI] [PMID: 23386483]
[EC created 2014]

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