ExplorEnz: EC 4.2.3.140

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4.2.3.140

Accepted name:

cis-abienol synthase

Reaction:

(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = cis-abienol + diphosphate

For diagram of hydroxylabdenyl diphosphate derived diterpenoids, click here

Glossary:

cis-abienol = (12Z)-labda-12,14-dien-8α-ol
(13E)-8α-hydroxylabd-13-en-15-yl diphosphate = 8-hydroxycopalyl diphosphate

Other name(s):

Z-abienol synthase; CAS; ABS

Systematic name:

(13E)-8α-hydroxylabd-13-en-15-yl-diphosphate-lyase (cis-abienol-forming)

Comments:

Isolated from the plants Abies balsamea (balsam fir) [1] and Nicotiana tabacum (tobacco) [2].

Links to other databases:

BRENDA, EXPASY, Gene, KEGG, MetaCyc

References:

1.	Zerbe, P., Chiang, A., Yuen, M., Hamberger, B., Hamberger, B., Draper, J.A., Britton, R. and Bohlmann, J. Bifunctional cis-abienol synthase from Abies balsamea discovered by transcriptome sequencing and its implications for diterpenoid fragrance production. J. Biol. Chem. 287 (2012) 12121–12131. [DOI] [PMID: 22337889]
2.	Sallaud, C., Giacalone, C., Topfer, R., Goepfert, S., Bakaher, N., Rosti, S. and Tissier, A. Characterization of two genes for the biosynthesis of the labdane diterpene Z-abienol in tobacco (Nicotiana tabacum) glandular trichomes. Plant J. 72 (2012) 1–17. [DOI] [PMID: 22672125]

[EC 4.2.3.140 created 2012]