| EC |
4.2.3.126 |
| Accepted name: |
γ-muurolene synthase |
| Reaction: |
(2E,6E)-farnesyl diphosphate = γ-muurolene + diphosphate |
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For diagram of cadinane sesquiterpenoid biosynthesis, click here |
| Glossary: |
γ-muurolene = (1S,4aS,8aR)-1-isopropyl-7-methyl-4-methylene-1,2,3,4,4a,5,6,8a-octahydronaphthalene |
| Other name(s): |
Cop3 |
| Systematic name: |
(2E,6E)-farnesyl-diphosphate diphosphate-lase (cyclizing, γ-muurolene-forming) |
| Comments: |
The enzyme has been characterized from the fungus Coprinus cinereus. Also gives germacrene A and α-muurolene, see EC 4.2.3.23, germacrene-A synthase and EC 4.2.3.125, α-muurolene synthase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc |
| References: |
| 1. |
Agger, S., Lopez-Gallego, F. and Schmidt-Dannert, C. Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus. Mol. Microbiol. 72 (2009) 1181–1195. [DOI] [PMID: 19400802] |
| 2. |
Lopez-Gallego, F., Wawrzyn, G.T. and Schmidt-Dannert, C. Selectivity of fungal sesquiterpene synthases: role of the active site’s H-1α loop in catalysis. Appl. Environ. Microbiol. 76 (2010) 7723–7733. [DOI] [PMID: 20889795] |
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| [EC 4.2.3.126 created 2012] |
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