The Enzyme Database

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Accepted name: bicyclogermacrene synthase
Reaction: (2E,6E)-farnesyl diphosphate = bicyclogermacrene + diphosphate
For diagram of bicyclogermacrene and avermitilol biosynthesis, click here
Other name(s): Ov-TPS4
Systematic name: (2E,6E)-farnesyl-diphosphate diphosphate-lyase (bicyclogermacrene-forming)
Comments: The enzyme from oregano (Origanum vulgare) gives mainly bicyclogermacrene with Mn2+ as a cofactor. With Mg2+ a more complex mixture is produced.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Crocoll, C., Asbach, J., Novak, J., Gershenzon, J. and Degenhardt, J. Terpene synthases of oregano (Origanum vulgare L.) and their roles in the pathway and regulation of terpene biosynthesis. Plant Mol. Biol. 73 (2010) 587–603. [DOI] [PMID: 20419468]
[EC created 2012]

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