EC |
4.2.2.8 |
Accepted name: |
heparin-sulfate lyase |
Reaction: |
Elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar. |
Other name(s): |
heparin-sulfate eliminase; heparitin-sulfate lyase; heparitinase I; heparitinase II |
Systematic name: |
heparin-sulfate lyase |
Comments: |
Does not act on N,O-desulfated glucosamine or N-acetyl-O-sulfated glucosamine linkages. |
Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37290-86-1 |
References: |
1. |
Hovingh, P. and Linker, A. The enzymatic degradation of heparin and heparitin sulfate. 3. Purification of a heparitinase and a heparinase from flavobacteria. J. Biol. Chem. 245 (1970) 6170–6175. [PMID: 5484472] |
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[EC 4.2.2.8 created 1972] |
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