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Your query returned 1 entry. Printable version
EC | 4.2.2.19 | ||||||||||||||||||||
Accepted name: | chondroitin B lyase | ||||||||||||||||||||
Reaction: | Eliminative cleavage of dermatan sulfate containing (1→4)-β-D-hexosaminyl and (1→3)-β-D-glucurosonyl or (1→3)-α-L-iduronosyl linkages to disaccharides containing 4-deoxy-β-D-gluc-4-enuronosyl groups to yield a 4,5-unsaturated dermatan-sulfate disaccharide (ΔUA-GalNAc-4S). | ||||||||||||||||||||
Glossary: | chondroitin sulfate B = dermatan sulfate For the nomenclature of glycoproteins, glycopeptides and peptidoglycans, click here |
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Other name(s): | chondroitinase B; ChonB; ChnB | ||||||||||||||||||||
Systematic name: | chondroitin B lyase | ||||||||||||||||||||
Comments: | This is the only lyase that is known to be specific for dermatan sulfate as substrate. The minimum substrate length required for catalysis is a tetrasaccharide [2]. In general, chondroitin sulfate (CS) and dermatan sulfate (DS) chains comprise a linkage region, a chain cap and a repeat region. The repeat region of CS is a repeating disaccharide of glucuronic acid (GlcA) and N-acetylgalactosamine (GalNAc) [-4)GlcA(β1-3)GalNAc(β1-]n, which may be O-sulfated on the C-4 and/or C-6 of GalNAc and C-2 of GlcA. GlcA residues of CS may be epimerized to iduronic acid (IdoA) forming the repeating disaccharide [-4)IdoA(α1-3)GalNAc(β1-]n of DS. Both the concentrations and locations of sulfate-ester substituents vary with glucosaminoglycan source [5]. | ||||||||||||||||||||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 52227-83-5 | ||||||||||||||||||||
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