The Enzyme Database

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Accepted name: nitrile hydratase
Reaction: an aliphatic amide = a nitrile + H2O
Other name(s): nitrilase (ambiguous); 3-cyanopyridine hydratase; NHase; L-NHase; H-NHase; acrylonitrile hydratase; aliphatic nitrile hydratase; nitrile hydro-lyase
Systematic name: aliphatic-amide hydro-lyase (nitrile-forming)
Comments: Acts on short-chain aliphatic nitriles, converting them into the corresponding amides. Does not act on these amides or on aromatic nitriles. cf. EC nitrilase.
Links to other databases: BRENDA, EAWAG-BBD, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 82391-37-5
1.  Asano, Y., Fujishiro, K., Tani, Y. and Yamada, H. Microbial degradation of nitrile compounds. 5. Aliphatic nitrile hydratase from Arthrobacter sp J-1. Purification and characterization. Agric. Biol. Chem. 46 (1982) 1165–1174.
[EC created 1989]

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