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Your query returned 1 entry. 
Printable version
| EC | 4.2.1.36 | ||||||
| Accepted name: | homoaconitate hydratase | ||||||
| Reaction: | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate = (Z)-but-1-ene-1,2,4-tricarboxylate + H2O | ||||||
| For diagram of l-lysine synthesis, click here | |||||||
| Glossary: | cis-homoaconitate = (Z)-but-1-ene-1,2,4-tricarboxylate (R)-homocitrate = (2R)-2-hydroxybutane-1,2,4-tricarboxylate homoisocitrate = (-)-threo-homoisocitrate = (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate |
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| Other name(s): | homoaconitase; cis-homoaconitase; HACN; Lys4; LysF; 2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase (incorrect) | ||||||
| Systematic name: | (1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming] | ||||||
| Comments: | Requires a [4Fe-4S] cluster for activity. The enzyme from the hyperthermophilic eubacterium Thermus thermophilus can catalyse the reaction shown above but cannot catalyse the previously described reaction, i.e. formation of (R)-homocitrate by hydration of cis-homoaconitate. The enzyme responsible for the conversion of cis-homoaconitate into (R)-homocitrate in T. thermophilus is unknown at present but the reaction can be catalysed in vitro using aconitate hydratase from pig (EC 4.2.1.3) [2]. | ||||||
| Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc, PDB, CAS registry number: 9030-68-6 | ||||||
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