| EC |
4.2.1.172 |
| Accepted name: |
trans-4-hydroxy-L-proline dehydratase |
| Reaction: |
trans-4-hydroxy-L-proline = (S)-1-pyrroline-5-carboxylate + H2O |
| Glossary: |
1-pyrroline = 3,4-dihydro-2H-pyrrole |
| Systematic name: |
trans-4-hydroxy-L-proline hydro-lyase |
| Comments: |
The enzyme has been characterized from the bacterium Peptoclostridium difficile. The active form contains a glycyl radical that is generated by a dedicated activating enzyme via chemistry involving S-adenosyl-L-methionine (SAM) and a [4Fe-4S] cluster. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Levin, B.J., Huang, Y.Y., Peck, S.C., Wei, Y., Martinez-Del Campo, A., Marks, J.A., Franzosa, E.A., Huttenhower, C. and Balskus, E.P. A prominent glycyl radical enzyme in human gut microbiomes metabolizes trans-4-hydroxy-L-proline. Science 355 (2017) . [DOI] [PMID: 28183913] |
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| [EC 4.2.1.172 created 2017] |
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