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Your query returned 1 entry. Printable version
EC | 4.2.1.166 | ||
Accepted name: | phosphinomethylmalate isomerase | ||
Reaction: | 2-(hydroxyphosphonoylmethyl)malate = 3-(hydroxyphosphonoylmethyl)malate (overall reaction) (1a) 2-(hydroxyphosphonoylmethyl)malate = 2-(phosphinatomethylidene)butanedioate + H2O (1b) 2-(phosphinatomethylidene)butanedioate + H2O = 3-(hydroxyphosphonoylmethyl)malate |
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Glossary: | 2-(hydroxyphosphonoylmethyl)malate = 2-hydroxy-2-(hydroxyphosphonoylmethyl)butanedioate 3-(hydroxyphosphonoylmethyl)malate = 2-hydroxy-3-(hydroxyphosphonoylmethyl)butanedioate |
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Other name(s): | pmi (gene name) | ||
Systematic name: | 2-(phosphinomethyl)malate hydro-lyase [3-(phosphinomethyl)malate-forming] | ||
Comments: | The enzyme, characterized from the bacterium Streptomyces viridochromogenes, is involved in bialaphos biosynthesis. The enzyme from the bacterium Kitasatospora phosalacinea participates in the biosynthesis of the related compound phosalacine. Both compounds contain the nonproteinogenic amino acid L-phosphinothricin that acts as a potent inhibitor of EC 6.3.1.2, glutamine synthetase. The similar enzyme EC 4.2.1.3, aconitate hydratase, cannot catalyse this reaction. | ||
Links to other databases: | BRENDA, EXPASY, KEGG, MetaCyc | ||
References: |
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