ExplorEnz: EC 4.2.1.158

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4.2.1.158

Accepted name:

galactarate dehydratase (D-threo-forming)

Reaction:

galactarate = (2S,3R)-2,3-dihydroxy-5-oxohexanedioate + H₂O

Glossary:

galactarate = (2R,3S,4R,5S)-2,3,4,5-tetrahydroxyhexanedioate
(2S,3R)-2,3-dihydroxy-5-oxohexanedioate = 3-deoxy-D-threo-hex-2-ulosarate

Systematic name:

galactarate hydro-lyase (3-deoxy-D-threo-hex-2-ulosarate-forming)

Comments:

The enzyme has been characterized from the bacterium Oceanobacillus iheyensis. cf. EC 4.2.1.42, galactarate dehydratase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

Rakus, J.F., Kalyanaraman, C., Fedorov, A.A., Fedorov, E.V., Mills-Groninger, F.P., Toro, R., Bonanno, J., Bain, K., Sauder, J.M., Burley, S.K., Almo, S.C., Jacobson, M.P. and Gerlt, J.A. Computation-facilitated assignment of the function in the enolase superfamily: a regiochemically distinct galactarate dehydratase from Oceanobacillus iheyensis. Biochemistry 48 (2009) 11546–11558. [DOI] [PMID: 19883118]

[EC 4.2.1.158 created 2015]