ExplorEnz: EC 4.2.1.155

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4.2.1.155

Accepted name:

(methylthio)acryloyl-CoA hydratase

Reaction:

3-(methylsulfanyl)acryloyl-CoA + 2 H₂O = acetaldehyde + methanethiol + CoA + CO₂ (overall reaction)
(1a) 3-(methylsulfanyl)acryloyl-CoA + H₂O = 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA
(1b) 3-hydroxy-3-(methylsulfanyl)propanoyl-CoA = 3-oxopropanoyl-CoA + methanethiol
(1c) 3-oxopropanoyl-CoA + H₂O = 3-oxopropanoate + CoA
(1d) 3-oxopropanoate = acetaldehyde + CO₂

Glossary:

3-(methylsulfanyl)acryloyl-CoA = 3-(methylsulfanyl)prop-2-enoyl-CoA

Other name(s):

DmdD

Systematic name:

3-(methylsulfanyl)prop-2-enoyl-CoA hydro-lyase (acetaldehyde-forming)

Comments:

The enzyme is involved in the degradation of 3-(dimethylsulfonio)propanoate, an osmolyte produced by marine phytoplankton. Isolated from the bacterium Ruegeria pomeroyi.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc, PDB

References:

1.	Tan, D., Crabb, W.M., Whitman, W.B. and Tong, L. Crystal structure of DmdD, a crotonase superfamily enzyme that catalyzes the hydration and hydrolysis of methylthioacryloyl-CoA. PLoS One 8:e63870 (2013). [DOI] [PMID: 23704947]

[EC 4.2.1.155 created 2015]