| EC |
4.2.1.138 |
| Accepted name: |
(+)-caryolan-1-ol synthase |
| Reaction: |
(+)-β-caryophyllene + H2O = (+)-caryolan-1-ol |
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For diagram of humulene-based sequiterpenoid biosynthesis, click here |
| Glossary: |
(+)-caryolan-1-ol = (1S,2R,5S,8R)-4,4,8-trimethyltricyclo[6.3.1.02,5]dodecan-1-ol |
| Other name(s): |
GcoA |
| Systematic name: |
(+)-β-caryophyllene hydrolase [cyclizing, (+)-caryolan-1-ol-forming] |
| Comments: |
A multifunctional enzyme which also forms (+)-β-caryophyllene from farnesyl diphosphate [EC 4.2.3.89, (+)-β-caryophyllene synthase]. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Nakano, C., Horinouchi, S. and Ohnishi, Y. Characterization of a novel sesquiterpene cyclase involved in (+)-caryolan-1-ol biosynthesis in Streptomyces griseus. J. Biol. Chem. 286 (2011) 27980–27987. [DOI] [PMID: 21693706] |
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| [EC 4.2.1.138 created 2011 as EC 3.7.1.15, transferred 2013 to EC 4.2.1.138] |
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