The Enzyme Database

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Accepted name: carotenoid 1,2-hydratase
Reaction: (1) 1-hydroxy-1,2-dihydrolycopene = lycopene + H2O
(2) 1,1′-dihydroxy-1,1′,2,2′-tetrahydrolycopene = 1-hydroxy-1,2-dihydrolycopene + H2O
For diagram of, click here and for diagram of mechanism, click here
Other name(s): CrtC
Systematic name: lycopene hydro-lyase (1-hydroxy-1,2-dihydrolycopene-forming)
Comments: In Rubrivivax gelatinosus [1] and Thiocapsa roseopersicina [2] both products are formed, whereas Rhodobacter capsulatus [1] only gives 1-hydroxy-1,2-dihydrolycopene. Also acts on neurosporene giving 1-hydroxy-1,2-dihydroneurosporene with both organism but 1,1′-dihydroxy-1,1′,2,2′-tetrahydroneurosporene only with Rubrivivax gelatinosus.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Steiger, S., Mazet, A. and Sandmann, G. Heterologous expression, purification, and enzymatic characterization of the acyclic carotenoid 1,2-hydratase from Rubrivivax gelatinosus. Arch. Biochem. Biophys. 414 (2003) 51–58. [DOI] [PMID: 12745254]
2.  Hiseni, A., Arends, I.W. and Otten, L.G. Biochemical characterization of the carotenoid 1,2-hydratases (CrtC) from Rubrivivax gelatinosus and Thiocapsa roseopersicina. Appl. Microbiol. Biotechnol. 91 (2011) 1029–1036. [DOI] [PMID: 21590288]
[EC created 2011]

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