The Enzyme Database

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Accepted name: tetrahymanol synthase
Reaction: tetrahymanol = squalene + H2O
For diagram of hopene and tetrahymanol biosynthesis, click here
Glossary: tetrahymanol = gammaceran-3β-ol
Systematic name: squalene hydro-lyase (tetrahymanol-forming)
Comments: The reaction occurs in the reverse direction.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Saar, J., Kader, J.C., Poralla, K. and Ourisson, G. Purification and some properties of the squalene-tetrahymanol cyclase from Tetrahymena thermophila. Biochim. Biophys. Acta 1075 (1991) 93–101. [DOI] [PMID: 1892870]
2.  Giner, J.L., Rocchetti, S., Neunlist, S., Rohmer, M. and Arigoni, D. Detection of 1,2-hydride shifts in the formation of euph-7-ene by the squalene-tetrahymanol cyclase of Tetrahymena pyriformis. Chem. Commun. (Camb.) (2005) 3089–3091. [DOI] [PMID: 15959594]
[EC created 2011]

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