The Enzyme Database

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Accepted name: cyclopenase
Reaction: (–)-cyclopenine = viridicatin + methyl isocyanate
For diagram of cyclopeptine, cyclopenine and viridicatin biosynthesis, click here
Glossary: (–)-cyclopenine = (3S,3′R)-4-methyl-3′-phenyl-1H-spiro[1,4-benzodiazepine-3,2′-oxirane]-2,5-dione
viridicatin = 3-hydroxy-4-phenyl-1H-quinolin-2-one
Other name(s): asqI (gene name)
Systematic name: (–)-cyclopenine methyl-isocyanate lyase (viridicatin-forming)
Comments: This fungal enzyme catalyses a key reaction in the biosynthesis of quinolone compounds, converting the benzodiazepine structure into a quinolone structure. The enzyme is also active with (–)-4′-methoxycyclopenine.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
1.  Kishimoto, S., Hara, K., Hashimoto, H., Hirayama, Y., Champagne, P.A., Houk, K.N., Tang, Y. and Watanabe, K. Enzymatic one-step ring contraction for quinolone biosynthesis. Nat. Commun. 9:2826 (2018). [DOI] [PMID: 30026518]
[EC created 2022]

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