| EC |
4.1.99.11 |
| Accepted name: |
benzylsuccinate synthase |
| Reaction: |
benzylsuccinate = toluene + fumarate |
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For diagram of anaerobic toluene catabolism, click here |
| Other name(s): |
benzylsuccinate fumarate-lyase |
| Systematic name: |
benzylsuccinate fumarate-lyase (toluene-forming) |
| Comments: |
A glycyl radical enzyme that is inhibited by benzyl alcohol, benzaldehyde, phenylhydrazine and is inactivated by oxygen. |
| Links to other databases: |
BRENDA, EAWAG-BBD, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 209264-18-6 |
| References: |
| 1. |
Beller, H.R. and Spormann, A.M. Analysis of the novel benzylsuccinate synthase reaction for anaerobic toluene activation based on structural studies of the product. J. Bacteriol. 180 (1998) 5454–5457. [PMID: 9765580] |
| 2. |
Leuthner, B., Leutwein, C., Schultz, H., Hörth, P., Haehnel, W., Schiltz, E., Schägger, H. and Heider, J. Biochemical and genetic characterisation of benzylsuccinate synthase from Thauera aromatica: a new glycyl radical enzyme catalysing the first step in anaerobic toluene metabolism. Mol. Microbiol. 28 (1998) 615–628. [DOI] [PMID: 9632263] |
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| [EC 4.1.99.11 created 2000] |
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