| EC |
4.1.3.6 |
| Accepted name: |
citrate (pro-3S)-lyase |
| Reaction: |
citrate = acetate + oxaloacetate |
| Other name(s): |
citrase; citratase; citritase; citridesmolase; citrate aldolase; citric aldolase; citrate lyase; citrate oxaloacetate-lyase; citrate oxaloacetate-lyase [(pro-3S)-CH2COO-→acetate] |
| Systematic name: |
citrate oxaloacetate-lyase (forming acetate from the pro-S carboxymethyl group of citrate) |
| Comments: |
The enzyme can be dissociated into components, two of which are identical with EC 2.8.3.10 (citrate CoA-transferase) and EC 4.1.3.34 (citryl-CoA lyase). EC 3.1.2.16, citrate lyase deacetylase, deacetylates and inactivates the enzyme. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9012-83-3 |
| References: |
| 1. |
Dagley, S. and Dawes, E.A. Citridesmolase: its properties and mode of action. Biochim. Biophys. Acta 17 (1955) 177–184. [DOI] [PMID: 13239657] |
| 2. |
Dimroth, P., Loyal, R. and Eggerer, H. Characterization of the isolated transferase subunit of citrate lyase as a CoA-transferase. Evidence against a covalent enzyme-substrate intermediate. Eur. J. Biochem. 80 (1977) 479–488. [DOI] [PMID: 336371] |
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| [EC 4.1.3.6 created 1961] |
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