| EC |
4.1.3.40 |
| Accepted name: |
chorismate lyase |
| Reaction: |
chorismate = 4-hydroxybenzoate + pyruvate |
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For diagram of ubiquinol biosynthesis, click here |
| Other name(s): |
CL; CPL; UbiC |
| Systematic name: |
chorismate pyruvate-lyase (4-hydroxybenzoate-forming) |
| Comments: |
This enzyme catalyses the first step in the biosynthesis of ubiquinone in Escherichia coli and other Gram-negative bacteria [1]. The yeast Saccharomyces cerevisiae can synthesize ubiquinone from either chorismate or tyrosine [3]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 157482-18-3 |
| References: |
| 1. |
Nichols, B.P. and Green, J.M. Cloning and sequencing of Escherichia coli ubiC and purification of
chorismate lyase. J. Bacteriol. 174 (1992) 5309–5316. [DOI] [PMID: 1644758] |
| 2. |
Siebert, M., Severin, K. and Heide, L. Formation of 4-hydroxybenzoate in Escherichia coli: characterization of the ubiC gene and its encoded enzyme chorismate pyruvate-lyase. Microbiology 140 (1994) 897–904. [DOI] [PMID: 8012607] |
| 3. |
Meganathan, R. Ubiquinone biosynthesis in microorganisms. FEMS Microbiol. Lett. 203 (2001) 131–139. [DOI] [PMID: 11583838] |
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| [EC 4.1.3.40 created 2007] |
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