| EC |
4.1.3.1 |
| Accepted name: |
isocitrate lyase |
| Reaction: |
isocitrate = succinate + glyoxylate |
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For diagram of the glyoxylate cycle, click here |
| Glossary: |
isocitrate = (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate (previously known as threo-Ds-isocitrate) |
| Other name(s): |
isocitrase; isocitritase; isocitratase; threo-Ds-isocitrate glyoxylate-lyase; isocitrate glyoxylate-lyase |
| Systematic name: |
isocitrate glyoxylate-lyase (succinate-forming) |
| Comments: |
The isomer of isocitrate involved is (1R,2S)-1-hydroxypropane-1,2,3-tricarboxylate [3]. |
| Links to other databases: |
BRENDA, EXPASY, Gene, GTD, KEGG, MetaCyc, PDB, CAS registry number: 9045-78-7 |
| References: |
| 1. |
McFadden, B.A. and Howes, W.V. Crystallisation and some properties of isocitrate lyase from Pseudomonas indigofera. J. Biol. Chem. 238 (1963) 1737–1742. |
| 2. |
Shiio, I., Shiio, T. and McFadden, B.A. Isocitrate lyase from Pseudomonas indigofera. I. Preparation, amino acid composition and molecular weight. Biochim. Biophys. Acta 96 (1965) 114–122. [DOI] [PMID: 14285253] |
| 3. |
Vickery, H.B. A suggested new nomenclature for the isomers of isocitric acid. J. Biol. Chem. 237 (1962) 1739–1741. [PMID: 13925783] |
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| [EC 4.1.3.1 created 1961] |
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