ExplorEnz: EC 4.1.2.67

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4.1.2.67

Accepted name:

2-dehydro-3,6-dideoxy-6-sulfo-D-galactonate aldolase

Reaction:

2-dehydro-3,6-dideoxy-6-sulfo-D-galactonate = (2S)-3-sulfolactaldehyde + pyruvate

Glossary:

2-dehydro-3,6-dideoxy-6-sulfo-D-galactonate = 3-deoxy-2-ketosulfogalactonate
(2S)-3-sulfolactaldehyde = (2S)-2-hydroxy-3-oxopropane-1-sulfonate

Other name(s):

3-deoxy-2-ketosulfogalactonate aldolase; SfcE

Systematic name:

2-dehydro-3,6-dideoxy-6-sulfo-D-galactonate (2S)-3-sulfolactaldehyde-lyase (pyruvate-forming)

Comments:

This enzyme, characterized from the bacterium Paracoccus wurundjeri strain Merri, participates in a sulfofucose degradation pathway. cf. EC 4.1.2.58, 2-dehydro-3,6-dideoxy-6-sulfogluconate aldolase.

Links to other databases:

BRENDA, EXPASY, KEGG, MetaCyc

References:

1.	Stewart, A.WE., Li, J., Lee, M., Lewis, J.M., Herisse, M., Hofferek, V., McConville, M.J., Pidot, S.J., Scott, N.E. and Williams, S.J. Tandem sulfofucolytic-sulfolactate sulfolyase pathway for catabolism of the rare sulfosugar sulfofucose. mBio 16:e0184025 (2025). [DOI] [PMID: 40823846]

[EC 4.1.2.67 created 2025]