| EC |
4.1.2.51 |
| Accepted name: |
2-dehydro-3-deoxy-D-gluconate aldolase |
| Reaction: |
2-dehydro-3-deoxy-D-gluconate = pyruvate + D-glyceraldehyde |
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For diagram of the Entner-Doudoroff pathway, click here |
| Other name(s): |
Pto1279 (gene name); KDGA; KDG-specific aldolase |
| Systematic name: |
2-dehydro-3-deoxy-D-gluconate D-glyceraldehyde-lyase (pyruvate-forming) |
| Comments: |
The enzyme from the archaeon Picrophilus torridus is involved in D-glucose and D-galactose catabolism via the nonphosphorylative variant of the Entner-Doudoroff pathway. In the direction of aldol synthesis the enzyme catalyses the formation of 2-dehydro-3-deoxy-D-gluconate and 2-dehydro-3-deoxy-D-galactonate at a similar ratio. It shows no activity with 2-dehydro-3-deoxy-D-gluconate 6-phosphate. cf. EC 4.1.2.14, 2-dehydro-3-deoxy-phosphogluconate aldolase. |
| Links to other databases: |
BRENDA, EXPASY, KEGG, MetaCyc, PDB |
| References: |
| 1. |
Reher, M., Fuhrer, T., Bott, M. and Schonheit, P. The nonphosphorylative Entner-Doudoroff pathway in the thermoacidophilic euryarchaeon Picrophilus torridus involves a novel 2-keto-3-deoxygluconate- specific aldolase. J. Bacteriol. 192 (2010) 964–974. [DOI] [PMID: 20023024] |
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| [EC 4.1.2.51 created 2013] |
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