The Enzyme Database

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EC 4.1.1.99     
Accepted name: phosphomevalonate decarboxylase
Reaction: ATP + (R)-5-phosphomevalonate = ADP + phosphate + isopentenyl phosphate + CO2
For diagram of the archaeal mevalonate pathway, click here
Systematic name: ATP:(R)-5-phosphomevalonate carboxy-lyase (adding ATP; isopentenyl-phosphate-forming)
Comments: The enzyme participates in a mevalonate pathway that occurs in halophilic archaea. The activity is also present in eubacteria of the Chloroflexi phylum. cf. EC 4.1.1.33, diphosphomevalonate decarboxylase, and EC 4.1.1.110, bisphosphomevalonate decarboxylase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc
References:
1.  Dellas, N., Thomas, S.T., Manning, G. and Noel, J.P. Discovery of a metabolic alternative to the classical mevalonate pathway. Elife 2:e00672 (2013). [PMID: 24327557]
2.  Vannice, J.C., Skaff, D.A., Keightley, A., Addo, J.K., Wyckoff, G.J. and Miziorko, H.M. Identification in Haloferax volcanii of phosphomevalonate decarboxylase and isopentenyl phosphate kinase as catalysts of the terminal enzyme reactions in an archaeal alternate mevalonate pathway. J. Bacteriol. 196 (2014) 1055–1063. [DOI] [PMID: 24375100]
3.  Thomas, S.T., Louie, G.V., Lubin, J.W., Lundblad, V. and Noel, J.P. Substrate Specificity and Engineering of Mevalonate 5-Phosphate Decarboxylase. ACS Chem. Biol. 14 (2019) 1767–1779. [PMID: 31268677]
[EC 4.1.1.99 created 2014, modified 2018]
 
 


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