| EC |
4.1.1.71 |
| Accepted name: |
2-oxoglutarate decarboxylase |
| Reaction: |
2-oxoglutarate = succinate semialdehyde + CO2 |
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For diagram of the citric acid cycle, click here |
| Glossary: |
thiamine diphosphate = 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-diphosphoethyl)-4-methyl-1,3-thiazolium |
| Other name(s): |
oxoglutarate decarboxylase; α-ketoglutarate decarboxylase; α-ketoglutaric decarboxylase; pre-2-oxoglutarate decarboxylase; 2-oxoglutarate carboxy-lyase |
| Systematic name: |
2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming) |
| Comments: |
Requires thiamine diphosphate. Highly specific. |
| Links to other databases: |
BRENDA, EXPASY, Gene, KEGG, MetaCyc, PDB, CAS registry number: 37205-42-8 |
| References: |
| 1. |
Shigeoka, S., Onishi, T., Maeda, K., Nakano, Y. and Kitaoka, S. Occurrence of thiamin pyrophosphate-dependent 2-oxoglutarate decarboxylase in mitochondria of Euglena gracilis. FEBS Lett. 195 (1986) 43–47. |
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| [EC 4.1.1.71 created 1989] |
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